Association of "natural" Antibodies to Gram-negative Bacteria with the Γ1-macroglobulins
نویسندگان
چکیده
"Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the gamma(1)-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating, mouse-protective, and opsonophagocytic activities of this fraction. Comparison with the antibody activity of gamma(2)-globulin of Cohn fraction II showed that up to 100 times more antibody activity on a weight basis was present in the macroglobulin fraction. These findings suggest that differences between natural and immune antibody result from the physicochemical properties of 2 different classes of immune globulin.
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 118 شماره
صفحات -
تاریخ انتشار 1963